Background clinical trials have established the efficacy of ranibizumab for the treatment of neovascular agerelated macular degeneration. Make pdf booklets, impose nup pages, combine pdf files, add watermarks, edit forms, add. Trial of transplantation of hcvinfected kidneys into uninfected recipients. Master protocols to study multiple therapies, multiple. A trial on peanut allergy, published in a trial on peanut allergy, published in february, indicates that allergen avoidance. Treatment of highly drugresistant pulmonary tuberculosis nejm. The new england journal of medicine is a publication of nejm group, a division of the massachusetts medical. Minimally invasive versus abdominal radical hysterectomy. Pci cure is a substudy of the clopidogrel in unstable angina to prevent recurrent events cure study. Is intensive glucose control with a gliclazide based regimen better than standard glucose control with a nongliclazide based regimen in high risk, but not too hard to control t2dm. We conducted a randomized trial comparing oral azithromycin with doxycycline. Assistant professor, division of infectious diseases.
The clopidogrel in unstable angina to prevent recurrent. The new england journal of medicine 1998 n engl j med 375. The cure for cholera the new england journal of medicine. At least seven new drugs approved in the last ten years most important and revolutionary are the socalled novel agents proteosome inhibitors. The clopidogrel in unstable angina to prevent recurrent events cure trial randomized 12,562 patients with uanstemi to either dual antiplatelet therapy with aspirin plus plavix or to aspirin alone immediately upon presentation. The results of the clopidogrel in unstable angina to prevent recurrent events cure study aug. Now includes the form filler for free oneoff license fee. Stem cells for scleroderma, new nejm article reports promise. In an openlabel, singlegroup study in which followup is ongoing at three south african sites, we investigated treatment with three oral drugs.
Trial of transplantation of hcvinfected kidneys into. Pci was performed after randomization at the discretion of the local investigator. A trial of darbepoetin alfa in type 2 diabetes and chronic. In the clopidogrel in unstable angina to prevent recurrent events trial cure, investigators evaluated the effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes acss without stsegment elevation.
The purpose of the cure trial, published in 2001, was to explore whether the addition of clopidogrel, a thienopyridine class antiplatelet agent, could further reduce the risk of recurrent. Trial oversight the established status epilepticus treatment trial esett was an investigatorinitiated, multicenter, randomized, blinded, comparativeeffectiveness trial of levetiracetam, fosphenytoin, and valproate for the treatment of patients with established status epilepticus in the emergency department. Ticagrelor versus clopidogrel in patients with acute coronary. Patients were eligible for the study if they had been hospitalized within 24 hours after the onset of symptoms and did not have stsegment elevation. Balanced crystalloids versus saline in noncritically ill. Balanced crystalloids versus saline in critically ill adults. This policy may be difficult to implement in other health systems, but imagine what prog1.
Use of vibrio cholerae vaccine in an outbreak n engl j med 370. Notable articles of 2015 the new england journal of. The new england journal of medicine m etastases are a major cause of complications and death among men with prostate cancer. It might surprise you to know that diabetes has been diagnosed as a disease since 1550 b. A randomized trial of intensive versus standard bloodpressure. Apalutamide treatment and metastasisfree survival in. This nejm publication recognizes the importance and robustness of the medalist study, as well as the. Acute bacterial sinusitis in children university of chicago. Jul 19, 2016 the trial aims to include 438 participants who are centrally randomized to one of the two treatment groups in a 1. At a mean followup of 9 months, dual antiplatelet therapy was associated with a significant reduction in. Effects of clopidogrel in addition to aspirin in patients. At 1 year, the mean systolic blood pressure was 121.
The results are published in the august 18, 2001 issue of the lancet, to coincide with the. Paul myles chair, rinaldo bellomo, tomas corcoran, chris christophi. The new england journal of medicine 1996 n engl j med 372. Kaitlin rainwaterlovett, phd, mph, priyanka uprety, and deborah persaud, md johns hopkins university martha sichonecameron, community lead december 2014 the hiv cure training curriculum is a collaborative project aimed at making hiv cure research science accessible to the community and the hiv research field. Supportive and attentive health care preferably with effective medications, but even without legitimately creates. The new england journal of medicine 2 n enl med nemor i ntravenous alteplase administered within 4. Stop trialn for patients with abnormal tcd, transfusion is superior to no. This trial makes an important contribution to our current medical knowledge, and.
Finally, the studies had a single test of cure within 2 to 5 weeks after treatment but did not have a repeat test at a later time to evaluate pa. The authors vouch for the completeness and accuracy of the data and for the adherence of the trial to the protocol, available with the full text of this article at. Concluded transfusion better than observation for secondary prevention. Participants in canvas were randomly assigned in a 1. Cure treated patients 312 months, with mean duration 9 months credo treated patients 12 months, but only 6264% of patients treated a full 12 months 2007 aha scientific statement based on somewhat nebulous conclusions from fda meeting and modest, nonrandomized and observational data nothing magical about 12 months or 365 days. Optimal antithrombotic treatments in patients with atrial fibrillation. In a prospective study, 697 patients with acute coronary syndromes underwent threevessel coronary. At 12 months, the ticagrelor group had lower rates of cv death, mi, or stroke than clopidogrel 9.
C cure clinical trial the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In revascularisation of left main coronary artery disease, pci was associated with an inferior clinical outcome at 5 years compared with cabg. Trial design and oversight the partial oral treatment of endocarditis poet trial was a nationwide investigatorinitiated, multi center, randomized, unblinded, noninferiority trial performed at cardiac centers in denmark. All the authors vouch for the adherence of the trial. Cutepdf convert to pdf for free, free pdf utilities. The 2009 platelet inhibition and patient outcomes plato trial randomized 18,624 patients with acs 37. A new nihfunded study reported in the new england journal of medicine nejm gives some hope for the use of a combination of a specific type. Correction of anemia with epoetin alfa in chronic kidney. Glecaprevirpibrentasvir for 8 or 12 weeks in hcv genotype. The cure trial was found to be of high quality jadad score 55. Notable articles of 2015 the new england journal of medicine. Pci cure was a prospectively designed study of patients undergoing pci who were randomised to doubleblind therapy with clopidogrel or placebo in the clopidogrel in unstable angina to prevent recurrent ischaemic events cure trial. Mortality was similar after the two procedures but patients treated with pci had higher rates of nonprocedural myocardial infarction and repeat revascularisation. Ranibizumab and bevacizumab for neovascular agerelated nejm.
The new engl and journal of medicine 2488 n engl j med 363. Antithrombotic therapy after acute coronary syndrome or. Randomized trial of primary pci with or without routine manual. Topline results alirocumab in patients after acute coronary syndrome.
When no cure is available an inevitable occurrence at some points medicines ultimate mission is to relieve unnecessary suffering. Sawyer at the department of surgery, university of virginia health system, box 800709, charlottesville, va 229080709. Canagliflozin and cardiovascular and renal events in type. Randomized trial of three anticonvulsant medications for. The new england journal of medicine 332 n engl j med 363.
In a pragmatic, clusterrandomized, multiplecrossover trial conducted in five inten sive care units at an academic center, we assigned 15,802 adults to receive saline 0. The sponsors of the trial had no role in the design or monitoring of the trial. Acute bacterial sinusitis in children is diagnosed on the basis of the history, with the use of the. A randomized trial of intraarterial treatment for acute. The new england journal of medicine is a publication of nejm group, a division of. The primary and secondary endpoints are discussed as well as inclusion and exclusion criteria. Sit trial debaun nejm 2014 n randomized scd 515 yo with silent stroke to receive regular blood transfusions or standard care observation group. Nejm landmark trial repository prepared 2122020 by. Reblozyl is not approved to treat mds in any geography. Background ticagrelor is an oral, reversible, directacting inhibitor of the adenosine diphosphate receptor p2y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogre. Listing a study does not mean it has been evaluated by the u.
The present trial was designed to examine the benefits and risks of a normal hematocrit in a large group of patients with cardiac disease who were undergoing hemodialysis. The clopidogrel in unstable angina to prevent recurrent events cure trial investigators are listed in the appendix. A trial of lopinavir ritonavir in adults hospitalized with severe covid19. Perioperative asa in noncardiac surgery had no cardiac protective benefit but did increase bleeding risk. Effects of pretreatment with clopidogrel and aspirin. Importantly, these data helped with the conundrum of treating prostate cancer. The new england journal of medicine 302 n engl j med 370. Jan 09, 2020 it is truly an honor to see work that began in acceleron laboratories more than a decade ago and advanced successfully through a collaboration with bristolmyers squibb now highlighted in the new england journal of medicine, said habib dable, president and chief executive officer of acceleron. Antithrombotic therapy for atrial fibrillation with stable coronary. The new england journal of medicine 2 n engl j med t he current ebola virus disease evd outbreak has resulted in more than 24,000 cases and 10,000 reported deaths as of. Initiation strategies for renalreplacement therapy in the. Oacalone openlabel trial comparing oral anticoagulation with. Cure was designed to evaluate if clopidogrel would further improve outcomes from acs when added to asa.
Trial oversight the established status epilepticus treatment trial esett was an investigatorinitiated, multicenter, randomized, blinded, comparativeeffectiveness trial of levetiracetam. In augustus, an industrysponsored, multinational trial. Nejm may 21, 2009 no difference in 30d deathmithrombosis between routine early use of eptifibatide and provisional use at the time of pci. Trial design the trial was a phase 3, multicenter, randomized trial with the primary objective to evaluate the hypothesis that laparoscopic or robotassisted radical hysterectomy minimally. However, the risk of major bleeding is increased among patients treated with clopidogrel. Coronary angiography after cardiac arrest without st. The new england journal of medicine 2086 n engl j med 355. Azithromycin versus doxycycline for urogenital chlamydia. Make pdf booklets, impose nup pages, combine pdf files, add watermarks, edit forms, add comments, add headers and footers, rearrange pages, security, digital signature, scan, ftp and much more. Alirocumab in patients with recent acute coronary syndrome. New tb clinical trials on the horizon 2 current state of dstb treatment combination therapy essential to prevent emergence of resistance current 6month regimen validated in clinical. Supportive therapy is the cornerstone of treatment.
A collection of articles selected by nejm editors new england. Methods study subjects in this randomized, prospective, openlabel trial, we studied. The new england journal of medicine downloaded from at uwmadison on october 31, 20. In a randomized, noninferiority trial published in nejm, li et al. The primary endpoint of the trial is overall survival assessed with a minimum followup of 36 months. Trial design and oversight our trial, the saline against lactated ringers or plasmalyte in the emergency department salted trial, was a singlecenter, pragmatic, unblinded, multiplecrossover trial.
New england journal of medicine publishes results of pivotal. Dolutegravir plus two different prodrugs of tenofovir to. Publication of the medalist trial results in a journal of such eminence will certainly help to. Doxycycline for chlamydia infection u rogenital chlamydia trachomatis in fection is the most prevalent bacterial. An independent data and safety monitoring board provided external oversight to ensure the safety of the trial participants. Themis is a randomized, doubleblind, placebocontrolled trial of ticagrelor versus placebo, on top of lowdose 75 to 150 mg aspirin. Lipid management for the prevention of atherosclerotic.
Backgroundduring primary percutaneous coronary intervention pci, manual thrombectomy may reduce distal embolization and thus improve. An openlabel pilot trial involving 10 patients shows that hepatitis c virus genotype 1infected kidneys transplanted into hcvnegative recipients, followed by directacting antiviral therapy, can result in excellent allograft function with cure of hcv infection. The trial was sponsored by the netherlands heart institute, biotronik, and astrazeneca. From the division of infectious diseases, department of pediatrics, university of wisconsin school of medicine and public health, madison. Partial oral versus intravenous antibiotic treatment of.
The antiplatelet agent clopidogrel has beneficial effects in patients with acute coronary syndromes without stsegment elevation. New england journal of medicine challenged our ways of thinking. Ccure clinical trial full text view clinicaltrials. Hrombosis caused by a ruptured or eroded atherosclerotic plaque is the usual underlying mechanism of acute coronary syndromes. Prasugrel effient vs clopidogrel plavix in patients with acs 1 trial to. In an openlabel, phase 3 trial, we randomly assigned 861 patients with previously untreated advanced clearcell renalcell carcinoma to receive pembrolizumab 200 mg intravenously once every 3 weeks plus axitinib 5 mg orally twice daily 432 patients or sunitinib 50 mg orally once daily for the first 4 weeks of each 6week cycle 429 patients. Use of vibrio cholerae vaccine in an outbreak in guinea. The purpose of the cure trial, published in 2001, was to explore whether the addition of clopidogrel, a thienopyridine class antiplatelet agent, could further reduce the risk of recurrent ischemic events in patients suffering from acs without stelevation. Aspirin in patients undergoing noncardiac surgery nejm 370. Effects of pretreatment with clopidogrel and aspirin followed. Ticagrelor with or without aspirin in highrisk patients.
A randomized trial of treatment for acute anterior. The trial also included a per protocol analysis which excluded those who received openlabel clopidogrel prior to pci. Percutaneous coronary angioplasty versus coronary artery. A recombinant vesicular stomatitis virus ebola vaccine. Abstract background there are limited data from randomized trials evaluating the use of antithrombotic therapy in patients with atrial fibrillation. Original article from the new england journal of medicine glecaprevirpibrentasvir for 8 or 12 weeks in hcv genotype 1 or 3 infection. A prospective naturalhistory study of coronary atherosclerosis.